Anemia in Inflammatory Bowel Disease: A Neglected Issue in Comprehensive Inflammatory Bowel Disease Management
Keywords:
Anemia, inflammatory bowel disease, ulcerative colitis, Crohn diseaseAbstract
Anemia is the most common extraintestinal inflammatory bowel disease (IBD) manifestations and is significantly correlated with several adverse impacts such as higher hospitalization rate, relapse rate, surgical intervention requirement, and low quality of life. The prevalence of anemia in IBD patients is greatly varied between reports, which is estimated between 8.8% to 74%. However, studies showed there were still gaps in the screening protocol and anemia treatment in daily practice. Anemia in IBD tends to be an overlooked IBD complication yet significant and must be adequately addressed. Anemia in IBD may be caused by several factors that interplayed, with iron deficiency anemia being the most common etiology. Comprehensive management of anemia in IBD should consist of active screening, evaluation of the etiology, holistic treatment, and follow-up monitoring. Optimization of IBD therapy should be emphasized because it also may improve the anemic condition. A multidisciplinary approach and collaboration are needed to ensure better IBD care.References
Guan Q. A comprehensive review and update on the pathogenesis of inflammatory bowel disease. J Immunol Res. 2019;2019.
Weiss G, Gasche C. Pathogenesis and treatment of anemia in inflammatory bowel disease. Haematologica. 2010;95(2):175–8.
Qureshi T, Peter NT, Wang R, et al. Improving anemia in inflammatory bowel disease: Impact of the anemia care pathway. Dig Dis Sci. 2019;64(8):2124–31.
Antunes CVDA, Neto AEH, Nascimento CRDA, et al. Anemia in inflammatory bowel disease outpatients: Prevalence, risk factors, and etiology. Biomed Res Int. 2015;2015.
Mücke V, Mücke MM, Raine T, et al. Diagnosis and treatment of anemia in patients with inflammatory bowel disease. Ann Gastroenterol. 2017;30(1):15–22.
Koutroubakis IE, Ramos-Rivers C, Regueiro M, et al. Five-year period prevalence and characteristics of anemia in a large us inflammatory bowel disease cohort. J Clin Gastroenterol. 2016;50(8):638–43.
Filmann N, Rey J, Schneeweiss S, et al. Prevalence of anemia in inflammatory bowel diseases in European countries: A systematic review and individual patient data meta-analysis. Inflamm Bowel Dis. 2014;20(5):936–45.
Burisch J, Vegh Z, Katsanos KH, et al. Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort-An ECCO-EpiCom study. J Crohn’s Colitis. 2017;11(10):1213–22.
Chaubal A, Pandey V, Choksi D, et al. Anemia in patients with ulcerative colitis in remission: A study from western India. Indian J Gastroenterol. 2017;36(5):361–5.
Atuʇ Ö, Kani HT, Banzragch M, et al. Incidence rate of anemia in inflammatory bowel diseases. Turkish J Gastroenterol. 2016;27(2):143–8.
Parra RS, Feitosa MR, Ferreira S, et al. Anemia and iron deficiency in inflammatory bowel disease patients in a referral center in brazil: Prevalence and risk factors. Arq Gastroenterol. 2020;57(3):272–7.
Wells CW, Lewis S, Barton JR, et al. Effects of changes in hemoglobin level on quality of life and cognitive function in inflammatory bowel disease patients. Inflamm Bowel Dis. 2006;12(2):123–30.
Michailidou M, Nfonsam VN. Preoperative anemia and outcomes in patients undergoing surgery for inflammatory bowel disease. Am J Surg. 2018;215(1):78–81.
Gafter-Gvili A, Schechter A, Rozen-Zvi B. Iron Deficiency Anemia in Chronic Kidney Disease. Acta Haematol. 2019;142(1):44–50.
Wallace DF. The Regulation of Iron Absorption and Homeostasis. Clin Biochem Rev. 2016;37(2):51–62.
Gasche C. Anemia in IBD: The overlooked villain. Inflamm Bowel Dis. 2000;6(2):142–50.
Pagani A, Nai A, Silvestri L, et al. Hepcidin and Anemia: A Tight Relationship. Front Physiol. 2019;10:1294.
Kaitha S, Bashir M, Ali T. Iron deficiency anemia in inflammatory bowel disease. World J Gastrointest Pathophysiol. 2015;6(3):62.
Singh UP, Singh NP, Murphy EA, et al. Chemokine and cytokine levels in inflammatory bowel disease patients. Cytokine. 2016;77:44–9.
Nemeth E, Ganz T. Anemia of inflammation. Hematol Oncol Clin North Am. 2014;28(4):671–81.
Tsiolakidou G, Koutroubakis IE. Stimulating erythropoiesis in inflammatory bowel disease associated anemia. World J Gastroenterol. 2007;13(36):4798–806.
Christodoulou DK, Tsianos EV. Anemia in inflammatory bowel disease - The role of recombinant human erythropoietin. Eur J Intern Med. 2000;11(4):222–7.
McLean LP, Cross RK. Adverse events in IBD: To stop or continue immune suppressant and biologic treatment. Expert Rev Gastroenterol Hepatol. 2014;8(3):223–40.
Park YE, Park SJ, Park JJ, et al. Incidence and risk factors of micronutrient deficiency in patients with IBD and intestinal Behçet’s disease: folate, vitamin B12, 25-OH-vitamin D, and ferritin. BMC Gastroenterol. 2021;21(1):1–9.
Huang S, Ma J, Zhu M, et al. Status of serum vitamin B12 and folate in patients with inflammatory bowel disease in China. Intest Res. 2017;15(1):103–8.
Niepel D, Klag T, Malek NP, et al. Practical guidance for the management of iron deficiency in patients with inflammatory bowel disease. Therap Adv Gastroenterol. 2018;11:1756284818769074.
Dignass AU, Gasche C, Bettenworth D, et al. European consensus on the diagnosis and management of iron deficiency and anaemia in inflammatory bowel diseases. J Crohn’s Colitis. 2015;9(3):211–22.
Jimenez K, Kulnigg-Dabsch S, Gasche C. Management of iron deficiency Anemia. Gastroenterol Hepatol. 2015;11(4):241–50.
Buttarello M. Laboratory diagnosis of anemia: are the old and new red cell parameters useful in classification and treatment, how? Int J Lab Hematol. 2016;38:123–32.
Fava C, Cattazzo F, Hu Z-D, et al. The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? Ann Transl Med. 2019;7(20):581–581.
Oustamanolakis P, Koutroubakis IE, Kouroumalis EA. Diagnosing anemia in inflammatory bowel disease: Beyond the established markers. J Crohn’s Colitis. 2011;5(5):381–91.
Gnanaraj J, Parnes A, Francis CW, et al. Approach to pancytopenia: Diagnostic algorithm for clinical hematologists. Blood Rev. 2018;32(5):361–7.
Dignass A, Farrag K, Stein J. Limitations of Serum Ferritin in Diagnosing Iron Deficiency in Inflammatory Conditions. Int J Chronic Dis. 2018;2018:1–11.
Pfeiffer CM, Looker AC. Laboratory methodologies for indicators of iron status: Strengths, limitations, and analytical challenges. Am J Clin Nutr. 2017;106(Suppl 6):1606S-1614S.
Peng YY, Uprichard J. Ferritin and iron studies in anaemia and chronic disease. Ann Clin Biochem. 2017;54(1):43–8.
Abitbol V, Borderie D, Polin V, et al. Diagnosis of iron deficiency in inflammatory bowel disease by transferrin receptor-ferritin index. Med (United States). 2015;94(26).
Lee T, Clavel T, Smirnov K, et al. Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD. Gut. 2016;66(5):863–71.
Stein J, Haas JS, Ong SH, et al. Oral versus intravenous iron therapy in patients with inflammatory bowel disease and iron deficiency with and without anemia in Germany - A real-world evidence analysis. Clin Outcomes Res. 2018;10:93–103.
Avnit T, Bieber A, Steinmetz T, et al. Treatment of anemia in inflammatory bowel disease- systematic review and meta-analysis. PLoS One. 2013;8(12):e75540.
Pergola PE, Fishbane S, Ganz T. Novel oral iron therapies for iron deficiency anemia in chronic kidney disease. Adv Chronic Kidney Dis. 2019;26(4):272–91.
Cotter J, Baldaia C, Ferreira M, et al. Diagnosis and treatment of iron-deficiency anemia in gastrointestinal bleeding: A systematic review. World J Gastroenterol. 2020;26(45):7242–57.
Sood A, Ahuja V, Kedia S, et al. Diet and inflammatory bowel disease: The Asian Working Group guidelines. Indian J Gastroenterol. 2019;38(3):220–46.
Bischoff SC, Escher J, Hébuterne X, et al. ESPEN practical guideline: Clinical Nutrition in inflammatory bowel disease. Clin Nutr. 2020;39(3):632–53.
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