The Effect of Ophiocephalus striatus Extract on the Levels of IGF-1 and Albumin in Elderly Patients with Hypoalbuminemia

Roza Mulyana, Siti Setiati, Rose D Martini, Kuntjoro Harimurti, Noto Dwimartutie

Abstract


Background: a freshwater fish Ophiocephalus striatus or known locally to Indonesian as haruan,can potentially increases IGF-1 and albumin levels in elderly patients with hypoalbuminemia due to the contents of amino acids, fatty acids, vitamins, and minerals. This study was conducted to investigate the effect of Ophiocephalus striatus extract on the level of IGF-1 and albumin in elderly patients with hypoalbuminemia.

Methods: the study is a double-blind randomized controlled trial involving malnourished elderly inpatients (≥60 years old) recovering from acute condition before hospital discharge, with Mini Nutritional Assessment score ≤23.5 and albumin level <3.5 g/dL. A total of 109 subjects were randomly divided into two groups: one group received 10 g Ophiocephalus striatus extract per day for 14 days and another group received placebo. Albumin and IGF-1 levels were obtained before and after intervention.

Results: ninety subjects completed the study (extract group=45 subjects; placebo group =45 subjects) for 14 days. The median of age were 69 (64;75) years and the male to female ratio were 2 : 3. The changes of IGF-1 and albumin levels from before to after intervention between extract group compared to placebo group were 14.7 (0.30;31.5) ng/mL vs 1.0 (-6;13.15) ng/mL (p=0.002) and 0.5 (0.15;0.70) g/dL vs 0.10 (0.0;0.50) g/dL (p=0.003), respectively. There were significant differences in the improvement of IGF-1 and albumin levels between extract and placebo group.

Conclusion: supplementation of Ophiocephalus striatus extract was associated with a significant increase in IGF-1 and albumin levels in elderly patients with hypoalbuminemia.


Keywords


Ophiocephalus striatus; IGF-1; albumin; elderly

References


Hsu HY, Hwang LC, Lin CH, Lin CJ, Tjung JJ. Impact of serum albumin on functional status and hospital outcome in oldest-old inpatients. Inter J of Geron. 2015;9:220-2.

Cabrerizo S, Cuadras D, Gomez-Busto F, Artaza-Artabe I, Ciancas FM, Malafarina V. Serum albumin and health in older people: review and meta analysis. Maturitas. 2015;81:17-27.

Wells JL, Dumbrell AC. Nutrition and aging: Assessment and treatment of compromised nutritional status in frail elderly patient. Clin Interv Aging. 2006;1:67-79.

Lara-Pulido A, Guevara-Cruz M. Malnutrition and associated factors in elderly hospitalized. Nutr Hosp. 2012;27(2):652-55.

Maggio M, De Vita F, Lauretani F, et al. IGF-1, the cross road of the nutritional, inflammatory and hormonal pathways to frailty. Nutrients. 2013;5:4184-205.

Paliliewu N, Datau EA, Matheos JC, Surachmanto EE. Channa striatus capsules induces cytokine conversion in pulmonary tuberculosis patients. J Exp Integr Med. 2013;3(3):1-6.

Retnanengsih. Pengaruh suplementasi ekstrak ikan gabus terhadap status protein, antioksidan, dan stres oksidatif serta keluaran klinis pada stroke iskemik akut [Disertasi]. Program Pascasarjana Universitas Diponegoro Semarang, 2014.

Bakar MR, Kadir AA, Wahab SZ, et al. Randomized controlled trial on the effect of Channa striatus extract on measurement of the uterus, pulsatility index, resistive index of uterine artery and superficial skin wound artery in post lower segment caesarean section women. Plos One. 2015; DOI:10.1371/journal.pone.0133514. Diakses tanggal 2 Januari 2016.

Bjorkman MP, Fienne-Soveri H, Tilvis RS. Whey protein supplementation in nursing home residents. A randomized controlled trial. Eur Ger Med. 2012;3:161-6.

Zhu K, Meng X, Kerr DA. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal women. J Bone Miner Res. 2011;26:2298–306.

Schurch MA, Rizzoli R, Slosman D, Vadas L, Vergnaud P, Bonjour JP. Protein supplements increase serum insulin-like growth factor-I levels and attenuate proximal femur bone loss in patients with recent hip fracture. A randomized, double-blind, placebo-controlled trial. Ann Intern Med. 1998;128:801-9.

Chevalley T, Hoffmeyer P, Bonjour JP, Rizzoli R. Early serum IGF-1 response to oral protein supplements in elderly women with a recent hip fracture. Clin Nutr. 2010;29:78-83.

Thalacker AE, Johnson CA, Yarasheki KE, Carnell NS, Campbell WW. Nutrient ingestion, protein intake, and sex, but not age, affect the albumin synthesis rate in humans. J Nutr. 2007;137(7):1734-40.

Vincent JL, Russel JA, Jacob M, et al. Albumin administration in the acute ill: what is new and where next. Crit Care. 2014;18:231.

Arai Y, Hirose N, Yamamura K, et al. Serum insulin-like gowth factor-1 in centenarians: implications of IGF-1 as a rapid turnover protein. J Gerontol A Biol Sci Med Sci. 2001;56(2):79-82.

Iwalewa EO, McGaw LJ, Naidoo V, Eloff N. Inflammation: the foundation of diseases and disorders. A review of phytomedicines of South African origin used to treat pain and inflammatory conditions. Afr J Biotechnol. 2007;6(25):2868-85.

Deutz NE, Bauer JM, Barazzoni R, et al. Protein intake and exercise for optimal muscle function with aging: recommendations from ESPEN expert group. Clin Nutr. 2014;33:929-36.


Full Text: PDF

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 Acta Medica Indonesiana