Subclinical Atherosclerosis in Young Adult Population with First Degree Relatives of Type 2 Diabetes Mellitus

Muhammad Syah Abdaly, Mohamad Syahrir Azizi, Ika Prasetya Wijaya, Pringgodigdo Nugroho, Dyah Purnamasari

Abstract


Cardiovascular disease (CVD) remain a leading cause of death globally. The concept of acute myocardial infarction in young adults was uncommon. Atherosclerosis is the leading cause of CVD, including myocardial infarction, stroke, heart failure and peripheral artery disease. This condition is initiated early in childhood and progressive in nature. CVD risk factors includes hypertension, dyslipidemia and obesity play a role in the development of atherosclerosis and  components in insulin resistance syndrome.

One of many risk factors for insulin resistance in healthy individuals is a first-degree relative (FDR) of Type 2 Diabetes Mellitus (T2DM) patients. This group shows a higher risk of insulin resistance and pancreatic beta cells disruption even in adolescence, although they often remains asymptomatic. Clinical manifestations of metabolic disorders and atherosclerosis will appear earlier in the FDR T2DM group who have sedentary lifestyles and obesity, when compared to the non-FDR group. Several studies have attempted to detect metabolic disorders and subclinical atherosclerosis that might occur; therefore an early prevention can be carried out in these high-risk groups.  Unfortunately, factors that affect the onset and the severity of the prospective clinical manifestations from the previous studies remained inconclusive.


Keywords


cardiovascular disease; atherosclerosis; first-degree relative; type 2 diabetes mellitus

References


Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR, Deo R, et al. Heart disease and strokes statistics’2017 update: a report from the American Heart Association. Circulation. 2017:146-603.

Erwinanto, Santoso A, Putranto JNE, Tedjasukmana P, Suryawan R, Rifqi S, et al. Coronary artery disease in the developing world. J Kardiol Indones. 2013;34(4):7–15.

Mahle T, Campbell RM, Sabatier JF. Myocardial infarction in adolescents. Pediatric Journal. 2007:150-54.

Harun RS. 2011. Gambaran faktor risiko pasien sindrom koroner akut usia muda dan non usia muda di ICCU RSCM Jakarta. Tesis. Jakarta: Universitas Indonesia.

Strong JP, Malcom GT, Mcmahan CA, Tracy RE, Iii WPN, Herderick EE, et al. Prevalence and extent of atherosclerosis in adolescents and young adults. JJAMAama. 1999;281(8):727–35.

Golden SH, Folsom AR, Coresh J, Sharrett a R, Szklo M, Brancati F. Risk factor groupings rRelated to insulin resistance and their synergistic effects on subclinical atherosclerosis. Diabetes. 2002;51(10):3069–76.

Federa TID. Prevalence of the metabolic syndrome among a racially / ethnically diverse group of U.S. eighth-grade adolescents and associations with fasting insulin and homeostasis model assessment of insulin. Diabetes. 2008;31(10):145.

Ammirati E, Moroni F, Norata GD, Magnoni M, Camici PG. Markers of inflammation associated with plaque progression and instability in patients with carotid atherosclerosis. Mediators Inflamm. 2015;Vol.2015:1-15.

Brolin EB, Agewall S, Brismar TB, Caidahl K, Tornvall P, Cederlund K. Neither endothelial function nor carotid artery intima-media thickness predicts coronary computed tomography angiography plaque burden in clinically healthy subjects: A cross-sectional study. BMC Cardiovasc Disord. BMC Cardiovascular Disorders; 2015;15(1):1–7.

Berry JD, Liu K, Folsom a R, Lewis CE, Carr JJ, Polak JF, et al. Prevalence and progression of subclinical atherosclerosis in younger adults with low short-term but high lifetime estimated risk for cardiovascular disease: the coronary artery risk development in young adults study and multi-ethnic study of atheroscleros. Circulation. 2009;119(3):382–9.

Defronzo RA, Ferrannini E. Insulin Resistance: A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease. Diabetes Care. 1991;14(3):173–94.

Beckmann JA, Creager MA, Libby P. Diabetes and atherosclerosis: Epidemiology, pathophysiology, and management. JAMA. 2002;287(19):2570–81.

Vaag A, Lehtovirta M, Thye-Ronn P, Groop L. Metabolic impact of a family history of type 2 diabetes. Results from a European multicentre study (EGIR). Diabet Med. 2001;18:533-40.

Rosenbaum M, Nonas C, Horlick M, Fennoy I, Vargas I, Schachner H, et al. Beta cell function and insulin sensitivity in early adolescence: Assosiation with body fatness and family history of type 2 diabetes mellitus. J Clin Endocrinol Metab. 2004;89:5469-76.

Haffner SM, Stern MP, Hazuda HP, Mitchell BD, Patterson JK. Increased insulin concentrations in nondiabetic offspring of diabetic patients. N Engl J Med. 1988: 319(20):1297-301

Warram JH, Martin BC, Krolewski S, Soeldner JS, Kahn CR. Slow glucose removal rate and hyperinsulinaemia precede the development of type II diabetes in the offspring of diabetic patients. Ann Inter Med. 1990;113:909–15.

Purnamasari D. 2006. Gambaran resistensi insulin pada saudara kandung subyek dengan diabetes melitus tipe 2. Tesis. Jakarta: Universitas Indonesia.

Kumar A, Tewari P, Sahoo SS. Type-2 diabetes mellitus patients : Aa prospective study in north indian. J Clin Biochem. 2005;20(2):10–7.

Meigs JB. Epidemiology of the insulin resistance syndrome. Current Diabetes Reports. 2003;3:73-9.

Tardif JC, Heinonen T, Orloff D, Libby P. Vascular biomarkers and surrogates in cardiovascular disease. Circulation. 2006;113(25):2936–42.

Toth PP. Subclinical atherosclerosis: What it is, what it means and what we can do about it. Int J Clin Pract. 2008;62(8):1246–54.

Amato M, Montorsi P, Ravani A, Oldani E, Galli S, Ravagani PM, et al. Carotid

intima media thickness by B-mode ultrasound as surrogate of coronary

atherosclerosis: correlation with quantitative coronary angiography and

intravascular ultrasound findings. Eur Heart J. 2007;28:2094-2101.

Onut R, Balanescu APS, Constantinescu D, Calmac L, Marinescu M, Dorobantu PM. Imaging atherosclerosis by carotid intima-media thickness in vivo: Hhow to, where and in whom. Mædica. 2012;7(2):153–62.

Koseoglu C, Kurmus O, Ertem AG, Colak B, Bilen E, Ipek G, et al. Association between carotid intima-media thickness and presence of coronary artery disease in chronic obstructive pulmonary disease patients. Anatol J Cardiol. 2016;16:601-7.

O’Leary DH, Polak JF: Intima-media thickness: a tool for atherosclerosis imaging and event prediction. Am J Cardiol 2002;90:18L–21L.

Lorenz MW, Markus HS, Bots ML, Rosvall M, Sitzer M. Prediction of clinical cardiovascular events with carotid intima-media thickness: A systematic review and meta-analysis. Circulation. 2007;115(4):459–67.

Balletshoefer BM, Rittig K, Enderle MD, Volk A, Maerker E, Jacob S, et al. Endothelial dDysfunction is dDetectable in yYoung nNormotensive fFirst-dDegree rRelatives of sSubjects with tType 2 dDiabetes in aAssociation with iInsulin rResistance. American Heart Association – Circulation. 2000;101;1780-84.

Sayed-Tabatabei F.A, Houwing-Duistermaat J.J, Van Duijn C.M, Witterman J.C. Angiotensin-conevrting enzyme gene polymorphism and carotid artery wall thickness: a meta-analysis. American Stroke Association – Stroke. 2003;34:1634-39.

Hung J, Mcquillan B.M, Nidorf M, Thompson P.L, Beilby J.P. Thickening in a community population angiotensin-converting enzyme gene polymorphism and carotid wall. American Heart Association – Arterioscler Thromb VasAsc Biol. 1999;19:1969-74.

Goldfine AB, Beckman JA, Betensky RA, Devlin H, Hurley S, Varo N, et al. Family history of diabetes is a major determinan of endothelial dysfunction. J Am Coll CaArdiol. 2006; 47:2456-61.

Van Den Ouweland JMW. 1Mutations in mitochondrial tRNALeu(UUR) gene in

a large pedigree with maternally transmitted type II diabetes mellitus and deafness.

Nat. Genet. 1992;1: 368–371.

Ozawa T. Mechanism of somatic mitochondrial DNA mutations associated with

age and diseases. Biochem Biophys Acta. 1995;1271: 177–189.

Cambien F. Deletion polymorphism in the gene for angiotensin-converting

enzyme is a potent risk factor for myocardial infarction. Nature. 1992;359: 641–644.

Viedt C. Differential activation of mitogen-activated protein kinases in smooth

muscle cells by angiotensin II: Iinvolvement of P22phox and reactive oxygen species.

Arterioscler. Thromb Vasc Biol. 2000; 20: 949–948

Pannacciulli N, Pergola GDP, Ciccone M, Rizzon P, Giorgino F, Giorgino R. Effect of family history of type 2 diabetes on the intima-media thickness of the common carotid artery in normal weight, overweight, and obese glucose-tolerant young adults. Diabetes Care. 2003;26(4):1230-4.

Ahmad J, Ahmed F, Siddiqui MA, Hameed B, Ahmad I. Inflammation, insulin resistance and carotid IMT in first degree relatives of north Indian type 2 diabetic subjects. Diabetes Res Clin Pract. 2006;73(2):205–10.

Dash DK, Choudhury AK, Singh M, Mangaraj S, Mohanty BK, Baliarsinha AK. Effect of parental history of diabetes on markers of inflammation, insulin resistance and atherosclerosis in first degree relatives of patients with type 2 diabetes mellitus. Diabetes Metab Syndr Clin Res Rev. Diabetes India; 2017.

Abdaly MS. 2019. Perbedaan tebal kompleks intima media arteri karotis antara first-degree relatives dan non first-degree relatives DM tipe 2 pada subjek dewasa muda normotensi dan normoglikemi. Tesis. Jakarta: Universitas Indonesia.

Deurenberg P, Deurenberg-Yap M, Guricci S. Asians are different from Caucasians and from each other in their body mass index/body fat per cent relationship. Obes Rev. 2002;3(3):141–6.

Pradeepa R, Gujral UP, Mohan V, Weber MB, Narayan KMV. Type 2 diabetes in South Asians: Similarities and differences with white Caucasian and other population. J Diabetes. Ann N Y Acad Sci. 2013;4(1):51-63.

Haffner SM. Insulin resistance, inflammation, and the prediabetic state. Am J Cardiol. 2003;92(4A):18–26.

Schmidt MI, Duncan BB, Sharrett AR, Lindberg G, Savage PJ, Offenbacher S, et al. Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study. Lancet. 1999;353(9165):1649–52.


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