Anal Swab in COVID-19 Patients

Sukamto Koesnoe, Rakhmad Hidayat, Muhammad Hafiz Aini, Devi Nurfadila Fani, Nita Widjaya

Abstract


In 2020, a new type of coronavirus (SARS-CoV-2) whose disease is called Coronavirus disease 2019 (COVID-19) has been reported. This virus was first discovered in Wuhan, China and has infected 90,308 people per March 2, 2020. As of the end of October 2020, more than 40 million people have been infected, with the death toll reaching 1,150,000 worldwide. Apart from respiratory tract infections, patients infected with this virus may exhibit other symptoms, such as diarrhea, abdominal pain, nausea, or vomiting. This means that the virus can be found in feces and anus, hence the anal swab can be used as a diagnostic tool for COVID-19 infection. The results of the specimen test show that the sensitivity of the nasopharyngeal swab positive detection rate is the highest and remains the gold standard for diagnosis. This sensitivity can also be influenced by the course of the disease that can infect the gastrointestinal tract so that anal PCR is performed for the diagnosis to detect the COVID-19 virus in patients.

Keywords


Coronavirus; COVID-19; Pneumonia; Gastrointestinal disease; Anal swab

References


Wu F, Zhao S, Yu B, et al. A new coronavirus associated with human respiratory disease in China. Nature. 2020;579:265−9.

Wrapp D, Wang N, Corbett KS, et al. Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. 2020;367(6483):1260−3.

Azwar MK, Kirana F, Kurniawan A, Handayani S, Setiati S. Gastrointestinal presentation in Covid-19 in Indonesia: a case report. Acta Med Indones. 2020;52(1):63−7.

Song Y, Liu P, Shi XL, et al. SARS-CoV-2 induced diarrhoea as onset symptom in patient with COVID-19. Gut. 2020 Jun;69(6):1143-4. doi: 10.1136/gutjnl-2020-320891.

World Health Organization. WHO Director-General’s opening remarks at the media briefing on COVID-19 - 11 March 2020 [Internet]. 2020 [updated 2020 March 11]. Available from: https://www.who.int/dg/speeches/detail/who-director-general-s-opening-remarks-at-the-media-briefing-on-covid-19---11- march-2020.

World Health Organization. Situation Report – 42 [Internet]. 2020 [updated 2020 March 02; cited 2020 March 15]. Available from: https://www.who.int/docs/default-source/ coronaviruse/situation-reports/20200302-sitrep-42-covid-19. pdf?sfvrsn=224c1add_2.

Kementerian Kesehatan Republik Indonesia. Info Infeksi Emerging Kementerian Kesehatan RI [Internet]. 2020 [updated 2020 March 30; cited 2020 March 31]. Available from: https:// infeksiemerging.kemkes.go.id/.

Rousan, L.A., Elobeid, E., Karrar, M. et al. Chest x-ray findings and temporal lung changes in patients with COVID-19 pneumonia. BMC Pulm Med. 2020;20:245. https://doi.org/10.1186/s12890-020-01286-5.

Teymouri M, Mollazadeh S, Mortazavi H, et al. Recent advances and challenges of RT-PCR tests for the diagnosis of COVID-19. Pathol Res Pract. 2021;221:153443. doi:10.1016/j.prp.2021.153443.

Abdullah M, Sudrajat DG, Muzellina VN, et al. The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients. BMJ Open Gastroenterol. 2021;8:e000590. doi: 10.1136/bmjgast-2020-000590.

Parasa S, Desai M, Thoguluva Chandrasekar V, et al. Prevalence of gastrointestinal symptoms and fecal viral shedding in patients with Coronavirus disease 2019: A systematic review and meta-analysis. JAMA Netw Open. 2020;3(6):e2011335. Published 2020 Jun 1. doi:10.1001/jamanetworkopen.2020.11335.

Harrison AG, Lin T, Wang P. Mechanisms of SARS-CoV-2 transmission and pathogenesis. Trends Immunol. 2020;41(12):1100-15. doi: 10.1016/j.it.2020.10.004. Epub 2020 Oct 14. PMID: 33132005; PMCID: PMC7556779.

Gu J, Korteweg C. Pathology and pathogenesis of severe acute respiratory syndrome. Am J Pathol. 2007;170(4):1136-47. doi: 10.2353/ajpath.2007.061088. PMID: 17392154; PMCID: PMC1829448.

Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal. 2020;10(2):102-8. doi: 10.1016/j.jpha.2020.03.001. Epub 2020 Mar 5. PMID: 32282863; PMCID: PMC7104082.

Boppana S, Qin K, Files JK, Russell RM, Stoltz R, Bibollet-Ruche F, Bansal A, Erdmann N, Hahn BH, Goepfert PA. SARS-CoV-2-specific circulating T follicular helper cells correlate with neutralizing antibodies and increase during early convalescence. PLoS Pathog. 2021;17(7):e1009761. doi: 10.1371/journal.ppat.1009761. PMID: 34270631; PMCID: PMC8318272.

Peng Y, Mentzer AJ, Liu G, et al. Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19. Nat Immunol. 2020;21:1336–45. https://doi.org/10.1038/s41590-020-0782-6.

Li L, Tan C, Zeng J, et al. Analysis of viral load in different specimen types and serum antibody levels of COVID-19 patients. J Transl Med. 2021;19(1):30. doi: 10.1186/s12967-020-02693-2. PMID: 33413461; PMCID: PMC7790347.

Cheuk S, Wong Y, Tse H, et al. Posterior oropharyngeal saliva for the detection of SARS-CoV-2. Clin Infect Dis. 2020. https://doi.org/10.1093/cid/ciaa797.


Full Text: PDF

Refbacks

  • There are currently no refbacks.