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  2. Vol 51, No 2 (2019)
  3. Hendarto

The Effect of Vitamin E Supplementation on Lipid Profiles and Adiponectin Levels in Obese Adolescents: A Randomized Controlled Trial

Aryono Hendarto, Ali K Alhadar, Damayanti R Sjarif

Abstract


Background: low-grade chronic inflammation in obese individuals contributes to the development of lipid abnormality and insulin resistance. Vitamin E has antioxidant and insulin-sensitizing properties, mediated by adiponectin. In this study, we aimed to evaluate the effect of vitamin E supplementation on lipid profiles and adiponectin levels in obese adolescents. Methods: this was a randomized, double-blind, controlled study. Obese adolescents aged 14-18 years, with no history of taking anti-obesity or antioxidant drugs, were recruited and randomized into two groups: vitamin E and placebo. The dose of vitamin E was 400 IU/day. Intervention was administered for two months. Lipid profiles and adiponectin levels were measured at baseline and after intervention. Primary outcomes were analyzed using the per-protocol analysis principle. Statistical analysis was performed using the independent t-test or the Mann-Whitney U test. Results: a total of 66 subjects completed the intervention study, 34 in the vitamin E group and 32 in the placebo group. Lipid profiles and adiponectin levels at 2 months after intervention did not differ significantly between the two groups. Changes from the baseline level were also not significantly different between the two groups and were inconsistent from one subject to another. Conclusion: in obese adolescents, vitamin E supplementation of 400 IU/day for 2 months does not significantly affect lipid profiles and adiponectin levels.

Keywords


vitamin E; lipid profiles; adiponectin; obesity; randomized controlled trial

References


Usfar AA, Lebenthal E, Atmarita, Achadi E, Soekirman, Hadi H. Obesity as a poverty-related emerging nutrition problems: The case of Indonesia. Obes Rev. 2010;11(12):924-8.

Hendarto A. The burden of childhood obesity in Indonesia. Int J Clin Pediatr Child Health. 2019;1(1):1-6.

Gungor NK. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol. 2014;6(3):129-43.

Marseglia L, Manti S, D’Angelo G, et al. Oxidative stress in obesity: A critical component in human diseases. Int J Mol Sci. 2015;16(1):378-400.

Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta. 2007;380(1-2):24-30.

Ruan H, Dong LQ. Adiponectin signaling and function in insulin target tissues. J Mol Cell Biol. 2016;8(2):101-9.

Tao C, Sifuentes A, Holland WL. Regulation of glucose and lipid homeostasis by adiponectin: Effects on hepatocytes, pancreatic β cells and adipocytes. Best Pract Res Clin Endocrinol Metab. 2014;28(1):43-58.

Achari AE, Jain SK. Adiponectin, a therapeutic target for obesity, diabetes, and endothelial dysfunction. Int J Mol Sci. 2017;18(6):1321.

Engler MM, Engler MB, Malloy MJ, et al. Antioxidant vitamins C and E improve endothelial function in children with hyperlipidemia: Endothelial Assessment of Risk from Lipids in Youth (EARLY) Trial. Circulation. 2003;108(9):1059-63.

Gray B, Swick J, Ronnenberg AG. Vitamin E and adiponectin: proposed mechanism for vitamin E-induced improvement in insulin sensitivity. Nutr Rev. 2011;69(3):155-61.

Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K. Gamma (γ) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (γ) expression in SW 480 human colon cancer cell lines. BMC Cancer. 2003;3:25.

Landrier JF, Gouranton E, El Yazidi C, et al. Adiponectin expression is induced by vitamin E via a peroxisome proliferator-activated receptor gamma-dependent mechanism. Endocrinol. 2009;150(12):5318-25.

Sutherland WHF, Manning PJ, Walker RJ, De Jong SA, Ryalls AR, Berry EA. Vitamin E supplementation and plasma 8‐isoprostane and adiponectin in overweight subjects. Obesity. 2012;15(2):386-91.

Hodis HN, Mack WJ, LaBree L, et al. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation. 2002;106(12):1453-9.

Sjarif DR, Nasar SS, Devaera Y, Tanjung CF. Asuhan nutrisi pediatrik. Jakarta: Ikatan Dokter Anak Indonesia; 2011.

Taylor RW, Jones IE, Williams SM, Goulding A. Evaluation of waist circumference, waist-to-hip ratio, and the conicity index as screening tools for high trunk fat mass, as measured by dual-energy X-ray absorptiometry, in children aged 3-19 y. Am J Clin Nutr. 2000;72(2):490-5.

Ikatan Dokter Anak Indonesia. Diagnosis dan tatalaksana sindrom metabolik pada anak dan remaja. Jakarta: Ikatan Dokter Anak Indonesia; 2014.

Kang M, Lee A, Yoo HJ, et al. Association between increased visceral fat area and alterations in plasma fatty acid profile in overweight subjects: a cross-sectional study. Lipids Health Dis. 2017;16:248.

Brites F, Martin M, Guillas I, Kontush A. Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit. BBA Clin. 2017;6:66-77.

Okosun RE, Adu ME. Effect of oral vitamin E supplementation on serum lipid profiles of apparently healthy Nigerians in Benin City. Trop J Pharm Res. 2015;14(6):1071-4.

Khabaz M, Rashidi M, Kaseb F, Afkhami-Ardekani M. Effect of vitamin E on blood glucose, lipid profile and blood pressure in type 2 diabetic patients. IJDO. 2009;1(1):11-5.

Uzum A, Toprak O, Gumustas MK, Ciftci S, Sen S. Effect of vitamin E supplementation on plasma lipid, apolipoprotein and lipoprotein profiles in patients on peritoneal dialysis and hemodialysis. Int J Nephrol Urol. 2010;2(2):320-9.

Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116(7):1784-92.

Gamberi T, Magherini F, Modesti A, Fiaschi T. Adiponectin signaling pathways in liver diseases. Biomedicines. 2018;6(2):52.

Neumeier M, Weigert J, Schaffer A, et al. Aldehyde oxidase 1 is highly abundant in hepatic steatosis and is downregulated by adiponectin and fenofibric acid in hepatocytes in vitro. Biochem Biohys Res Commun. 2006;350(3):371-5.

Buechler C, Wanninger J, Neumeier M. Adiponectin, a key adipokine in obesity related liver diseases. World J Gastroenterol. 2011;17(23):2801-11.

Kim AY, Park YJ, Pan X, et al. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nat Commun. 2015;6:7585.

Engin A. Adiponectin-resistance in obesity. Adv Exp Med Biol. 2017;960:415-41.

Rasmussen MS, Lihn AS, Pedersen SB, Bruun JM, Rasmussen M, Richelsen B. Adiponectin receptors in human adipose tissue: effects of obesity, weight loss, and fat depots. Obesity (Silver Spring). 2006;14(1):28-35.

Mohammadi-Sartang M, Dashtabi A, Mazloom Z. Vitamin E supplementation and circulating adiponectin concentrations: A systematic review and meta-analysis of randomized controlled trials. Int J Nutr Sci. 2017;2(3):118-25.


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