Factors Associated with Death in COVID-19 Patients in Jakarta, Indonesia: An Epidemiological Study

Anna Rozaliyani, Ary Indriana Savitri, Findra Setianingrum, Titania Nur Shelly, Vini Ratnasari, Romala Kuswindarti, Ngabila Salama, Dwi Oktavia, Widyastuti Widyastuti, Diah Handayani

Abstract


Background: Coronavirus Disease 2019 is an emerging respiratory disease that is now a pandemic. Indonesia is experiencing a rapid surge of cases but the local data are scarce. Methods: this is an analysis using data from the ongoing recapitulation of Epidemiological Surveillance (ES) by the Provincial Health Office of Jakarta from March 2nd to April 27th 2020. We evaluated demographic and clinical characteristics of all confirmed cases in association with death. Results: of the 4,052 patients, 381 (9.4%) patients were deceased. Multivariable analysis showed that death was associated with older age (odds ratio [OR] 1.03; 95% confidence interval [CI] 1.02, 1.05, per year increase; p<0.001), dyspnea (OR 4.83; 95% CI 3.20, 7.29; p<0.001), pneumonia (OR 2.46; 95%CI 1.56, 3.88; p<0.001), and pre-existing hypertension (OR 1.86; 95% CI 1.24, 2.78; p=0.003). Death was highest in the week of April 6th 2020 and declined in the subsequent weeks, after a large-scale social restriction commenced. Conclusion: older age, dyspnea, pneumonia, and pre-existing hypertension were associated with death. Mortality was high, but may be reduced by lockdown.


Keywords


COVID-19; death; Indonesia; Jakarta; patient characteristics

References


Ceraolo C, Giorgi FM. Genomic variance of the 2019 nCoV coronavirus. Med Virol. 2020;92(5):522–8.

Li Q, Guan X, Wu P, et al. Early transmission dynamics in Wuhan, China, of novel Coronavirus–infected pneumonia. N Engl J Med. 2020;382(13):1199–207.

World Health Organization. Coronavirus disease (COVID-19) Situation Report 22 May 2020. (May):1–18. https://www.who.int/docs/default-source/coronaviruse/situation-reports/20200522-covid-19-sitrep-123.pdf?sfvrsn=5ad1bc3_4.

Ministry of Health Republic of Indonesia. Dua pasien positif Covid-19 dirawat di RSPI Sulianti Saroso. https://www.kemkes.go.id/article/view/20030200009/dua-pasien-positif-covid-19-dirawat-di-rspi-sulianti-saroso.html (2020, accessed May 25, 2020).

Setiati S, Azwar MK. COVID-19 and Indonesia. Acta Med Indones. 2020;52(1):84–9.

Ministry of Health Republic of Indonesia. Situasi terkini perkembangan novel Coronavirus (COVID-19) - 22 Mei 2020. https://covid19.kemkes.go.id/situasi-infeksi-emerging/info-corona-virus/situasi-terkini-perkembangan-coronavirus-disease-covid-19-23-mei-2020/#.XsvE9GhKjIU (2020).

Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020;395(10229):1054–62.

Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with Coronavirus Disease 2019 Pneumonia in Wuhan, China. JAMA Intern Med. 2020;E1–E10.

Du R, Liang L, Yang C, et al. Predictors of mortality for patients with COVID-19 pneumonia caused by SARS- CoV-2 : a prospective cohort study. Eur Respir J. 2020;56(1):1–8.

Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective , observational study. Lancet Respir Med. 2020;8(5):475–81.

Du Y, Tu L, Zhu P, et al. Clinical features of 85 fatal cases of COVID-19 from Wuhan: a retrospective observational study. Am J Respir Crit Care Med. 2020;201(11):1372–9.

Zheng Z, Peng F, Xu B, et al. Risk factors of critical & mortal COVID-19 cases: A systematic literature review and meta-analysis. J Infect. 2020;81(2):e16–e25.

Wu Z, Jennifer M. Characteristics of and important lessons from the Coronavirus Disease 2019 (COVID-19) outbreak in China summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020;323(13):1239–42.

Chen N, Zhou M, Dong X, et al. Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 2020;395(10223):P507-513.

Hanff TC, Harhay MO, Brown TS, Cohen JB, Mohareb AM. Is there an association between COVID-19 mortality and the renin-angiotensin system? a call for epidemiologic investigations. Clin Infect Dis. 2020;71(15):870–4.

Zheng Y-Y, Ma Y-T, Zhang J-Y, Xie X. COVID-19 and the cardiovascular system. Nat Rev Cardiol. 2020;17(5):259–60.

Wang X, Fang X, Cai Z, et al. Comorbid chronic diseases and acute organ injuries are strongly correlated with disease severity and mortality among COVID-19 patients : A systemic review and meta-analysis. Am Assoc Adv Sci. 2020;1–16.

Docherty AB, Harrison EM, Green CA, et al. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO clinical characterisation protocol: Prospective observational cohort study. BMJ. 2020;369(m1985):1–12.

Petrilli CM, Jones SA, Yang J, et al. Factors associated with hospital admission and critical illness among 5279 people with coronavirus disease 2019 in New York City: prospective cohort study. BMJ. 2020;369(m1966):1–15.

Hasell J, Mathieu E, Beltekian D, et al. Coronavirus (COVID-19) testing statistics and research. https://ourworldindata.org/coronavirus-testing#indonesiaaccessed (2020).

Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. J Am Med Assoc. 2020;323(11):1061–9.

Ji Y, Ma Z, Peppelenbosch MP, Pan Q. Potential association between COVID-19 mortality and health care resource availability. Lancet Glob Heal. 2020;8(4):e480.

Statistical Unit Special Capital Region of Jakarta. Pelaporan Kematian Periode Januari-Desember 2019 dan Januari-April 2020 di Provinsi DKI Jakarta. http://statistik.jakarta.go.id/pelaporan-kematian-periode-januari-desember-2019-dan-januari-april-2020-di-provinsi-dki-jakarta/ (2020).

Provincial Health Office of Special Capital Region of Jakarta. Poin penting PSBB di DKI Jakarta. (April): https://corona.jakarta.go.id/id/publikasi (2020).

Lewnard J, Co N. Scientific and ethical basis for social-distancing interventions against COVID-19. Lancet Infect Dis. 2020;20(6):631–3.

Stein RA. COVID-19 and rationally layered social distancing. Int J Clin Pract. 2020;14(00):e13501.

Paital B, Das K, Kumar S. Science of the Total Environment Inter nation social lockdown versus medical care against COVID-19, a mild environmental insight with special reference to India. Sci Total Environ. 2020;728(138914):1–18.

COVID-19 National Incident Room Surveillance Team. COVID-19, Australia: Epidemiology Report 15. 2020. p. 1–26.


Full Text: PDF

Refbacks

  • There are currently no refbacks.