Validation of Indonesian Graves’ Ophthalmopathy Quality of Life Questionnaire and Its Association with Clinical Activity and Severity of Graves’ Ophthalmopathy

Authors

  • Cecilia Anggraini Residency Program in Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Syntia Nusanti Neuro-ophthalmology Division, Department of Ophthalmology, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
  • Dicky Levenus Tahapary Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia
  • Levina Chandra Khoe Department of Community Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia

Keywords:

Graves Ophthalmopathy, Quality of Life, Questionnaire, Indonesian GO-QoL

Abstract

Background: Graves’ ophthalmopathy (GO) ocular abnormalities can persist even after treatment, negatively impacting patients’ psychological and social health. The Indonesian Graves’ Ophthalmopathy Quality of Life (GO-QoL) Questionnaire has not been validated, hence it cannot measure patient quality of life, which is crucial to GO treatment. We aimed to provide a reliable Indonesian GO-QoL Questionnaire and identify an association between patient quality of life and clinical activity and the severity of GO. Methods: The process of questionnaire validation involves transcultural adaptation and a cross-sectional design. The content validity index (CVI) and Cronbach’s alpha assessed validity and reliability, respectively. Results: The CVI was 1.00 for the Indonesian GO-QoL questionnaire. The Cronbach’s alpha for the visual function subscale value was 0.971, the appearance subscale value was 0.993, and the total score was 0.986. The appearance subscale and total score of GO patients’ quality of life had a significant association with clinical activity score (p<0.05) and disease severity (p<0.001). Conclusion: The Indonesian version of the GO-QoL has good validity and reliability. Both the active clinical activity of GO and the severity of the disease decreased patients’ appearance and general quality of life.

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Published

2025-01-21

How to Cite

Anggraini, C., Nusanti, S., Tahapary, D. L., & Khoe, L. C. (2025). Validation of Indonesian Graves’ Ophthalmopathy Quality of Life Questionnaire and Its Association with Clinical Activity and Severity of Graves’ Ophthalmopathy. Acta Medica Indonesiana, 56(4), 461. Retrieved from https://actamedindones.org/index.php/ijim/article/view/2647

Issue

Vol. 56 No. 4 (2024): Acta Medica Indonesiana

Section

ORIGINAL ARTICLE

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