Regulatory T Cell Immunity in Atherosclerosis

Authors

  • Hilman Zulkifli Amin Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
  • Naoto Sasaki Department of Medical Pharmaceutics, Kobe Pharmaceutical University, Kobe, Japan
  • Ken-Ichi Hirata Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan

Keywords:

Atherosclerosis, regulatory T cells, inflammation

Abstract

Atherosclerosis is a chronic inflammatory disorder involving innate and adaptive immunity process. Effector T cell (Teff) responses promote atherosclerotic disease, whereas regulatory T cells (Tregs) have been shown to play a protective role against atherosclerosis by down-regulating inflammatory responses which include multiple mechanisms. Compelling experimental data suggest that shifting the Treg/Teff balance toward Tregs may be a possible therapeutic approach for atherosclerotic disease, although the role of Tregs in human atherosclerotic disease has not been fully elucidated. In this review, we discuss recent advances in our understanding of the roles of Tregs and Teffs in experimental atherosclerosis, as well as human coronary artery disease.

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Published

2017-05-10

How to Cite

Amin, H. Z., Sasaki, N., & Hirata, K.-I. (2017). Regulatory T Cell Immunity in Atherosclerosis. Acta Medica Indonesiana, 49(1), 63-68. Retrieved from https://actamedindones.org/index.php/ijim/article/view/352

Issue

Vol. 49 No. 1 (2017): Acta Medica Indonesiana

Section

REVIEW ARTICLE

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