Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population

Authors

  • Zulkhair Ali Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia
  • Ida Kusrini Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia
  • Alwi Shahab Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia
  • Irsan Saleh Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, South Sumatera, Indonesia

Keywords:

angiotensin II type-1 receptor, polymorphism, diabetic nephropathy

Abstract

Background: diabetic nephropathy (DN) is the leading cause of blood dialysis worldwide and a major etiology of End-Stage Renal Disease cases in Indonesia. Previous studies showed a relevant link between A1166C polymorphism of Angiotensin II Type-1 Receptor (AT1R) gene and glomerular hyper-filtration as a part of pathogenesis of DN. The aim of this study was to elaborate the association between A1166C AT1R polymorphism and susceptibility of individual with type-2 diabetes to DN in Malay Indonesian population. Methods: a case-control study of 120 consecutive patients with type-2 diabetes mellitus (40 patients in each groups for macro-albuminuria, micro-albuminuria, and normo-albuminuria) was conducted for A1166C AT1R gene polymorphism. The A1166C polymorphism of the AT1R gene was determined based on PCR/RFLP. Results: the mutant C allele was found in 5%, 13.75%, and 12.5% in normo-, micro-, and macro-albuminuria patients respectively. The heterozygote AC genotype was found significantly higher in micro-albuminuria, compared to normo-albuminuria group. Heterozygote AC genotype (OR 3.2 [1.01-10.08], p=0.03) and C allele (OR 2.8[0.95-8.67], p=0.038) were significantly higher in DN, indicating A1166C AT1R gene polymorphism as a risk factor for DN in Malay Indonesian population with type-2 diabetes. Conclusion: there was positive association between A1166C AT1R polymorphism and susceptibility of type-2 diabetics to DN in Malay Indonesian Population. It also indicated that the A1166C AT1R polymorphism could play a role in early pathogenesis of DN.

Author Biographies

Zulkhair Ali, Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia

Division of Nephrology and Hypertension, Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia

Ida Kusrini, Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia

Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang

Alwi Shahab, Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia

Division of Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine Universitas Sriwijaya – Mohammad Hoesin Hospital, Palembang, South Sumatera, Indonesia

Irsan Saleh, Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, South Sumatera, Indonesia

Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, South Sumatera, Indonesia

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Published

2019-01-11

How to Cite

Ali, Z., Kusrini, I., Shahab, A., & Saleh, I. (2019). Association between A1166C Polymorphism of the Angiotensin II Type-1 Receptor Gene and Type-2 Diabetic Nephropathy in an Indonesian Malay Population. Acta Medica Indonesiana, 50(4), 314. Retrieved from https://actamedindones.org/index.php/ijim/article/view/806

Issue

Vol. 50 No. 4 (2018): Acta Medica Indonesiana

Section

ORIGINAL ARTICLE

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