Association Between ABO Blood Groups and Malaria Severity in a Regional Referral Hospital in Jayapura Papua, Indonesia
Abstract
Background: Malaria infection has caused a significant morbidity and mortality, notably in high-risk groups. Some evidence showed that ABO blood types might associate with malaria severity. This study aimed to determine the relationship between blood types and malaria severity in Papua, as Papua is a malaria-endemic area. Methods: A cross-sectional study was conducted in a regional referral hospital in Jayapura, Indonesia. Diagnosis of malaria was determined using World Health Organization criteria and classified into severe and uncomplicated malaria. Blood types were classified into O and non-O groups. Results: Out of 210 patients, 84 (40%) and 126 (60%) patients had non-O and O blood types, respectively. Severe malaria was more prevalent in non-O compared to O blood type (16.7% vs. 9.5%; the prevalence ratio (PR) was 2.4; 95% CI 1.06-6.42; p value 0.032). Amongst non-O groups, group B blood type demonstrated the highest incidence of severe malaria (p value 0.038; 95% CI: 1.06-6.42). Conclusion: There is an association between ABO blood group and the severity of malaria in Papua. Severe malaria was found more in non-O blood types, especially type B blood group.
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References
World Health Organization, 2022. World Malaria Report 2022 [internet]. available from: world malaria report 2022 (who.int). Accessed August 31, 2023
Ministry of Health Republic of Indonesia, 2021. Hari Malaria Sedunia Tahun 2021. Avaialable from: http://p2p.kemkes.go.id/hari-malaria-sedunia-tahun-2021/. Accessed September 29, 2023.
Ministry of Health Republic of Indonesia, 2021. Profil Kesehatan Indonesia 2021 [internet]. Accessed September 10, 2023
Degarege A, Gebrezgi MT, Ibanez G, Wahlgren M, Madhivanan P. Effect of the ABO blood group on susceptibility to severe malaria: A systematic review and meta-analysis. Blood Rev. 2019;33:53-62.
Wolofsky KT, Ayi K, Branch DR, et al. ABO blood groups influence macrophage-mediated phagocytosis of Plasmodium falciparum-infected erythrocytes. PLoS Pathog. 2012;8:e1002942
Deepa, Alwar VA, Rameshkumar K, Ross C. ABO blood groups and malaria related clinical outcome. J Vector Borne Dis. 2011;48:7-11.
Thakur A, Verma IC. Malaria and ABO blood groups. Indian J Malariol. 1992;29:241-4.
Fowkes FJI, Michon P, Pilling L, et al. Host erythrocyte polymorphisms and exposure to Plasmodium falciparum in Papua New Guinea. Malaria Journal. 2008;7:1.
Cserti CM, Dzik WH. The ABO blood group system and Plasmodium falciparum malaria. Blood. 2007;110: 2250-8.
Panda AK, Panda SK, Sahu AN, Tripathy R, Ravindran B, Das BK. Association of ABO blood group with severe falciparum malaria in adults: case control study and meta-analysis. Malaria Journal. 2011;10:309.
Barragan A, Kremsner PG, Wahlgren M, Carlson J. Blood group A antigen is a coreceptor in Plasmodium falciparum rosetting. Infect Immun. 2000;68:2971-5.
Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM. Repeated clinical malaria episodes are associated with modification of the immune system in children. BMC Med. 2019;17:60.
Rowe JA, Handel IG, Thera MA, et al. Blood group O protects against severe Plasmodium falciparum malaria through the mechanism of reduced rosetting. Proc Natl Acad Sci U S A. 2007;104:17471-6.
Phadungsil W, Krenc AG. The correlation between blood group antigens and malaria. J Hematol Transfus Med. 2018;28:2
Abegaz SB. Human ABO blood groups and their associations with different diseases. Biomed Res Int. 2021. doi: 10.1155/2021/6629060. PMID: 33564677; PMCID: PMC7850852.
Chaorattanakawee S, Nuchnoi P, Hananantachai H, et al. Correction: Sequence variation in Plasmodium falciparum merozoite surface protein-2 is associated with virulence causing severe and cerebral malaria. PLOS ONE. 2018;13:4
Jaskiewicz E, Jodłowska M, Kaczmarek R. Erythrocyte glycophorins as receptors for Plasmodium merozoites. Parasites Vectors. 2019;12:317.
Barua P, Beeson JG, Maleta K, Ashorn P, Rogerson SJ. The impact of early life exposure to Plasmodium falciparum on the development of naturally acquired immunity to malaria in young Malawian children. Malaria Journal. 2019;18:11.
Ai L, Li J, Wang W, Li Y. ABO blood group and risk of malaria during pregnancy: a systematic review and meta-analysis. Epidemiology and Infection. 2022; 150:1.
Nasr Z, Jalali F, Ahmed D, Wilby K. Sodium-glucose cotransporter-2 inhibitors and cardiovascular outcomes in type 2 diabetes mellitus: A systematic review. Saudi Journal for Health Sciences. 2012;1:16-22.
Yeda R, Okudo C, Owiti E, et al. Burden of malaria infection among individuals of varied blood groups in Kenya. Malaria Journal. 2022;21:251.
Doolan DL, Dobaño C, Baird JK. Acquired immunity to malaria. Clin Microbiol Rev. 2009;22:13-36.
Hietanen J, Chim-Ong A, Sattabongkot J, Nguitragool W. Naturally induced humoral response against Plasmodium vivax reticulocyte binding protein 2P1. Malar J. 2021:20.
Bediako Y, Adams R, Reid AJ, Valletta JJ, Ndungu FM. Repeated clinical malaria episodes are associated with modification of the immune system in children. BMC Med. 2019;17:60.
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