Effect of Listening to Quran Recitation on the Quality of Life of Systemic Lupus Erythematosus Patients: A Quasi-Experimental Study
Keywords:
Quran, Recitation, systemic lupus erythematosus, Quality of lifeAbstract
Background: Quality of life (QoL) is not sufficiently considered in current systemic lupus erythematosus (SLE) treatment targets, even though it’s significantly impaired. Studies have shown that higher religiousness is associated with a higher QoL. This study aimed to determine the effect of listening to Quran recitations on the QoL of SLE patients. Methods: A quasi-experimental study with a pretest-posttest study design was conducted at Cipto Mangunkusumo Hospital, Jakarta. Participants were females aged 18 years or older with SLE, Muslim, and not experiencing hearing loss. Those who didn’t regularly listen to the Quran were assigned to the control group. The intervention group consisted of patients who had previously listened to the Quran on a more regular basis, as well as those who had not. The intervention group listened to a Quran (QS. Ar-Rahman) for a minimum duration of 15 minutes, twice daily, for 40 days. A comparison of the effects of listening to the Quran within the group was conducted using a paired T-test, with a Wilcoxon test applied when necessary. p-values of less than 0.05 were considered statistically significant. Results: A total of 65 participants were included in the study, with 32 in the intervention group and 33 in the control group. The results indicated a significant increase in QoL in the intervention group (p=0.023). Additionally, there was a reduction in anxiety levels within the intervention group (p=0.030). Conclusion: Listening to Quran recitation can enhance QoL, while also decreasing anxiety in patients with SLE.References
Justiz Vaillant AA, Goyal A, Varacallo MA. Systemic lupus erythematosus. 2025.
Tian J, Zhang D, Yao X, et al. Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study. Ann Rheum Dis. 2023;82(3):351-6.
Jiang M, Near AM, Desta B, et al. Disease and economic burden increase with systemic lupus erythematosus severity 1 year before and after diagnosis: a real-world cohort study, United States, 2004–2015. Lupus Sci Med. 2021;8(1):e000503.
Basta F, Fasola F, Triantafyllias K, et al. Systemic lupus erythematosus (SLE) therapy: The old and the new. Rheumatol Ther. 2020;7(3):433-46.
Kernder A, Elefante E, Chehab G, et al. The patient’s perspective: Is quality of life and disease burden a possible treatment target in systemic lupus erythematosus? Rheumatology (Oxford). 2020;59(Suppl 5):v63-8.
Refai RH, Hussein MF, Abdou MH, et al. A case–control study on health-related quality of life of systemic lupus erythematosus patients. Sci Rep. 2024;14(1):5234.
World Health Organization. WHOQOL: measuring quality of life. Geneva: World Health Organization; 2012.
Borges CC, dos Santos PR, Alves PM, et al. Association between spirituality/religiousness and quality of life among healthy adults: a systematic review. Health Qual Life Outcomes. 2021;19(1):246.
Chai PPM, Krägeloh CU, Shepherd D, et al. Stress and quality of life in international and domestic university students: cultural differences in the use of religious coping. Ment Health Relig Cult. 2012;15(3):265-77.
Hsien-Chuan Hsu P, Krägeloh CU, Shepherd D, et al. Religion/spirituality and quality of life of international tertiary students in New Zealand: an exploratory study. Ment Health Relig Cult. 2009;12(4):385-99.
Krägeloh CU, Henning MA, Billington R, et al. The relationship between quality of life and spirituality, religiousness, and personal beliefs of medical students. Acad Psychiatry. 2015;39(1):85-9.
Deb S, Strodl E. Quality of life and spirituality in Indian university students. Appl Res Qual Life. 2019;14(2):393-408.
Felicilda-Reynaldo RFD, Cruz JP, Papathanasiou IV, et al. Quality of life and the predictive roles of religiosity and spiritual coping among nursing students: A multi-country Study. J Relig Health. 2019;58(5):1573-91.
Lau WWF, Hui CH, Lam J, et al. The relationship between spirituality and quality of life among university students: An autoregressive cross-lagged panel analysis. High Educ. 2015;69(6):977-90.
Pillay N, Ramlall S, Burns JK. Spirituality, depression, and quality of life in medical students in KwaZulu-Natal. S Afr J Psychiatry. 2016;22(1):6.
Casu G, Ulivi G, Zaia V, et al. Spirituality, infertility‐related stress, and quality of life in Brazilian infertile couples: Analysis using the actor‐partner interdependence mediation model. Res Nurs Health. 2018;41(2):156-65.
Dadkhahtehrani T, Momenyan S, Heidari S, et al. Association between the religious coping of infertile people with their own quality of life and their spouses’: A correlation study in Iranian infertile couples. Iran J Nurs Midwifery Res. 2018;23(3):198-204.
Gonçalves LM, Tsuge MLT, Borghi VS, et al. Spirituality, religiosity, quality of life and mental health among pantaneiros: A study involving a vulnerable population in Pantanal Wetlands, Brazil. J Relig Health. 2018;57(6):2431-43.
Al-Galal SA, Fakhri Taha Alshaikhli I. Analyzing brainwaves while listening to Quranic recitation compared with listening to music based on EEG signals. International Journal on Perceptive and Cognitive Computing. 2017;3(1).
Saleem S, Saleem T. Efficacy of music and Quranic verses in reducing cortisol level: A stress biomarker in medical undergraduates. Curr Psychol. 2023;42(8):6229-34.
Teimourzadeh M, Babamohamadi H, Yarmohamadi M, et al. The effect of the holy Quran recitation on inflammatory markers in hemodialysis patients in Iran: A randomized clinical trial. J Relig Health. 2024;63(6):4826-39.
Zarea Gavgani V, Ghojazadeh M, Sadeghi-Ghyassi F, et al. Effects of listening to Quran recitation on anxiety reduction in elective surgeries: A systematic review and meta-analysis. Arch Psychol Relig. 2022;44(2):111-26.
Ghiasi A, Keramat A. The effect of listening to holy quran recitation on anxiety: A systematic review. Iran J Nurs Midwifery Res. 2018;23(6):411.
Jabbari B, Mirghafourvand M, Sehhatie F, et al. The effect of holy Quran voice with and without translation on stress, anxiety, and depression during pregnancy: a randomized controlled trial. J Relig Health. 2020;59(1):544-54.
Rafique R, Anjum A, Raheem SS. Efficacy of surah Al-Rehman in managing depression in Muslim women. J Relig Health. 2019;58(2):516-26.
Moulaei K, Haghdoost A, Bahaadinbeigy K, et al. The effect of the holy Quran recitation and listening on anxiety, stress, and depression: A scoping review on outcomes. Health Sci Rep. 2023;6(12).
Hindmarch T, Dalrymple J, Smith M, et al. Spiritual interventions for cancer pain: a systematic review and narrative synthesis. BMJ Support Palliat Care. 2022;12(1):1-9.
Che Wan Mohd Rozali WNA, Ishak I, Mat Ludin AF, et al. The impact of listening to, reciting, or memorizing the Quran on physical and mental health of Muslims: evidence from a systematic review. Int J Public Health. 2022;67.
Frih B, Mkacher W, Bouzguenda A, et al. Effects of listening to holy Qur’an recitation and physical training on dialysis efficacy, functional capacity, and psychosocial outcomes in elderly patients undergoing haemodialysis. Libyan J Med. 2017;12(1):1372032.
Eid Aburuz M, Al-Dweik G, Ahmed FR. The effect of listening to holy Quran recital on pain and length of stay post‐CABG: A randomized controlled trial. Crit Care Res Pract. 2023;2023(1).
World Medical Association Declaration of Helsinki. JAMA. 2013;310(20):2191.
McElhone K, Abbott J, Shelmerdine J, et al. Development and validation of a disease‐specific health‐related quality of life measure, the LupusQol, for adults with systemic lupus erythematosus. Arthritis Care Res (Hoboken). 2007;57(6):972-9.
Anindito B, Hidayat R, Koesnoe S, et al. Validity And reliability of lupus quality of life questionnaire in patients with systemic lupus erythematosus in Indonesia. Indonesian Journal of Rheumatology. 2018;8(2).
Guzmán J, Cardiel MH, Arce-Salinas A, et al. Measurement of disease activity in systemic lupus erythematosus. Prospective validation of 3 clinical indices. J Rheumatol. 1992;19(10):1551-8.
Uribe AG, Vilá LM, McGwin G, et al. The systemic lupus activity measure-revised, the Mexican systemic lupus erythematosus disease activity index (SLEDAI), and a modified SLEDAI-2K are adequate instruments to measure disease activity in systemic lupus erythematosus. J Rheumatol. 2004;31(10):1934-40.
Snaith RP. The hospital anxiety and depression scale. Health Qual Life Outcomes. 2003;1(1):29.
Tiksnadi BB, Triani N, Fihaya FY, et al. Validation of hospital anxiety and depression scale in an Indonesian population: a scale adaptation study. Fam Med Community Health. 2023;11(2):e001775.
Shatri H, Purnamandala, Hidayat R, et al. The correlation of anxiety and depression with C3 and C4 Levels and systemic lupus erythematosus activity. BMC Psychiatry. 2023;23(1):785.
Osama Abdel Fattah, Ayed Ali Zureigat. The effect of the holy Quran voice on the quality of life among the elderly during the coronavirus outbreak. International Journal of Psychosocial Rehabilitation. 2020;24(08):983-93.
Minjie Z, Zhijuan X, Xinxin S, et al. The effects of cognitive behavioral therapy on health-related quality of life, anxiety, depression, illness perception, and atrial fibrillation patients: a six-month longitudinal study. BMC Psychol. 2023;11(1):431.
Feng HX, Wang MX, Zhao HM, et al. Effect of cognitive behavioral intervention on anxiety, depression, and quality of life in patients with epilepsy. Am J Transl Res. 2022;14(7):5077-87.
Kannan MA, Ab Aziz NA, Ab Rani NS, et al. A review of the holy Quran listening and its neural correlation for its potential as a psycho-spiritual therapy. Heliyon. 2022;8(12):e12308.
Levine GN, Lange RA, Bairey-Merz CN, et al. Meditation and cardiovascular risk reduction. J Am Heart Assoc. 2017;6(10).
Zhang L, Fu T, Yin R, et al. Prevalence of depression and anxiety in systemic lupus erythematosus: a systematic review and meta-analysis. BMC Psychiatry. 2017;17(1):70.
Ratanasiripong NT, Ratanasiripong P. Predictive factors of quality of life among systemic lupus erythematosus patients in Thailand: a web-based cross-sectional study. Qual Life Res. 2020;29(9):2415-23.
Chen HJ, Wang H, Qiu LJ, et al. Relation among anxiety, depression, sleep quality, and health-related quality of life among patients with systemic lupus erythematosus: Path analysis. Patient Prefer Adherence. 2022;16:1351-8.
Jolly M, Katz P. Predictors of stress in patients with Lupus. Front Med (Lausanne). 2022;9.
Patterson S, Trupin L, Hartogensis W, et al. Perceived stress and prediction of worse disease activity and symptoms in a multiracial, multiethnic systemic lupus erythematosus cohort. Arthritis Care Res (Hoboken). 2023;75(8):1681-9.
DeQuattro K, Trupin L, Patterson S, et al. Positive psychosocial factors may protect against perceived stress in people with systemic lupus erythematosus with and without trauma history. Lupus Sci Med. 2024;11(1):e001060.
Zajkowska Z, Walsh A, Zonca V, et al. A systematic review of the association between biological markers and environmental stress risk factors for adolescent depression. J Psychiatr Res. 2021;138:163-75.
Remes O, Mendes JF, Templeton P. Biological, psychological, and social determinants of depression: A review of recent literature. Brain Sci. 2021;11(12):1633.
Narmandakh A, Roest AM, de Jonge P, et al. Psychosocial and biological risk factors of anxiety disorders in adolescents: a TRAILS report. Eur Child Adolesc Psychiatry. 2021;30(12):1969-82.
Wang F, Ma X, Zhao L, et al. The influence of genetic and environmental factors on anxiety among Chinese adolescents: A twin study. J Genet Psychol. 2024;185(6):415-26.
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Copyright (c) 2026 Karina Wijayanti, Alvina Widhani, Sukamto Koesnoe , Rudi Putranto , Anshari Saifuddin Hasibuan, Eka Ginanjar , Teguh Harjono Karjadi, Chyntia Olivia Maurine Jasirwan , Pringgodigdo Nugroho
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