Sticky Platelet Syndrome as a Cause of Recurrent Miscarriages: A Rare Case Report
Abstract
Sticky platelet syndrome (SPS) is a hereditary disorder. SPS can cause pregnancy complications, such as recurrent miscarriages. However, proper management can prevent the incidence of recurrent miscarriages. Here, we describe a case of a woman who lost her fifth first-trimester pregnancy, and upon assessment, we discovered SPS. The 33-year-old woman underwent consultation with an obstetrician because of her history of five first-semester miscarriages. Gynecology ultrasound, infection parameters, hormonal and metabolic panels, and autoimmune workup were all found to be normal; however, vitamin D deficiency was identified as was SPS from a platelet aggregation test. The patient was then treated with clopidogrel and vitamin D3 supplementation. She became pregnant after five months of treatment. Her pregnancy was normal and she went into delivery at 40 weeks gestation with no maternal or fetal complications.References
Kubisz P, Stasko J, Holly P. Sticky platelet syndrome. Semin Thromb Hemost. 2013;39:674–83. Available from: http://dx.doi.org/10.1055/s-0033-1353394. [cited 8 September 2023]
Ruiz-Arguelles GJ, Garces-Eisele J, Camacho-Alarcon C, et al. Primary thrombophilia in Mexico IX: The glycoprotein IIIa PLA1/A2 polymorphism is not associated with the sticky platelet syndrome. Phenotype Clinical and Applied Thrombosis/ Hemostasis. 2012; 19(6):689-92. DOI: 10.1177/1076029612448418. [cited 8 September 2023]
Kubisz P, Stanciakova L, Stasko J, Dobrotova M, Skerenova M, Ivankova J. Sticky platelet syndrome: an important cause of life-threatening thrombotic complications. Expert Review of Hematology. 2015; 1747-4094. DOI:10.1586/17474086.2016.1121095. [cited 28 August 2023]
Ruiz-Delgado GJ, Cantero-Fortiz Y, Mendez-Huerta MA, et al. Primary Thrombophilia in Mexico XII: Miscarriages are more frequent in people with sticky platelet syndrome. Turk J Hematol. 2017;2017;34:239-43. DOI: 10.4274/tjh.2016.0411. [cited 1 September 2023]
Stanciaková L, Žolková J, Vadelová L, et al. DNA Polymorphisms in pregnant women with sticky platelet syndrome. J. Clin. Med. 2022;11:6532. https://doi.org/ 10.3390/jcm11216532. [cited 1 October 2023]
Skerenova M, Sokol J, Biringer K, et al. GP6 haplotype of missense variants is associated with sticky platelet syndrome manifested by fetal loss. Clinical and Applied Thrombosis/Hemostasis. 2018;24(1):63-9. DOI: 10.1177/1076029616685428. [cited 1 September 2023]
Alecsandru D, Klimczak AM, Garcia Velasco JA, Pirtea P, Franasiak JM. Immunologic causes and thrombophilia in recurrent pregnancy loss. Fertil Steril. 2021;115(3):561-6. doi: 10.1016/j.fertnstert.2021.01.017.[cited 1 October 2023]
Ford HB, Schust DJ. Recurrent pregnancy loss: Etiology, diagnosis, and therapy. Reviews in Obstetrics & Gynecology Spring. 2009;2(2):76-83. PMCID: PMC2709325. [cited 14 September 2023]
van Dijk MM, Kolte AM, Limpens J, Kirk E, Quenby S, van Wely M, Goddijn M. Recurrent pregnancy loss: diagnostic workup after two or three pregnancy losses? A systematic review of the literature and meta-analysis. Hum Reprod Update. 2020;26(3):356-367. doi: 10.1093/humupd/dmz048.[cited 10 October 2023]
Shehata H, Ali A, Silva-Edge M, Haroon S, Elfituri A, Viswanatha R, Jan H, Akolekar R. Thrombophilia screening in women with recurrent first-trimester miscarriage: is it time to stop testing? - a cohort study and systematic review of the literature. BMJ Open. 2022;12(7):e059519. doi: 10.1136/bmjopen-2021-059519. [cited 1 October 2023]
Sokol J, Skerenova M, Biringer K, Simurda T, Kubisz P, Stasko J. Glycoprotein VI gene variants Affect Pregnancy Loss in Patients With Platelet hyperaggregability. 2018. Clinical and Applied Thrombosis/Hemostasis. 2018;24(9S):202S-208S. DOI: 10.1177/1076029618802358. [cited 1 September 2023]
Hayes C, Kitahara S, Tcherniantchouk O. Decreased threshold of aggregation to low-dose epinephrine is evidence of platelet hyperaggregability in patients with thrombosis. 2014. Hematology Reports. 2014;6:5326. DOI:10.4081/hr.2014.5326. [cited 10 September 2023]
Vallejo-Villalobos MF, Gomez-Cruz GB, Cantero-Fortiz Y, et al. Primary thrombophilia XIV: Worldwide identification of sticky platelet syndrome. Semin Thromb Hemost. 2019;45:423–8. DOI https://doi.org/10.1055/s-0039-1688498. [cited 10 September 2023]
Moncada B, Ruíz-Arguelles GJ, Martínez CC. The sticky platelet syndrome. Hematology. 2013;18:4, 230-2, DOI: 10.1179/1607845412Y.0000000068. [cited 10 September 2023]
Kubisz P, Holly P, Stasko J. Sticky platelet syndrome: 35 years of growing evidence. Seminars in Thrombosis & Hemostasis. 2019;45(1):61-8. DOI https://doi.org/10.1055/s-0038-1676581. [cited 10 September 2023]
Kubisz P, Ruiz-Argüelles GJ, Stasko J, Holly P, Ruiz-Delgado GJ. Sticky platelet syndrome: History and future perspectives. Semin Thromb Hemost. 2014;40:526–34. DOI http://dx.doi.org/10.1055/s-0034-1381235. [cited 8 September 2023]
Yagmur E, Bast E, Mühlfeld AS, Koch A, Weiskirche R, Tacke F. High prevalence of sticky platelet syndrome in patients with infertility and pregnancy loss. J. Clin. Med. 2019;8:1328; doi:10.3390/jcm8091328. [cited 10 September 2023]
Bick RL. Platelet-function defects. In: Bick RL, ed. Disorder of thrombosis and hemostasis: clinical and laboratory practice 3rd ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 59-85.
García-Villaseñor E, Bojalil-Álvarez L, Murrieta-Álvarez I, Cantero-Fortiz Y, Ruiz-Delgado GJ, Ruiz-Argüelles GJ. Primary thrombophilia XVI: A look at the genotype of the sticky platelet syndrome phenotype. Clinical and Applied Thrombosis/ Hemostasis. 2021;27:1–8. DOI:10.1177/10760296211044212. [cited 8 September 2023]
Sokol J, Skerenova M, Jedinakova Z, Simurda T, Skornova I, Stasko J. Progress in the understanding of sticky platelet syndrome. Semin Thromb Hemost. 2017;43(1);8-13. DOI http://dx.doi.org/10.1055/s-0036-1584352. [cited 2 September 2023]
Solis-Jimenez F, Hinojosa-Heredia H, García-Covarrubias L, Soto-Abraham V, Valdez-Ortiz R. Case report sticky platelet syndrome: An unrecognized cause of acute thrombosis and graft loss. 2018. Article ID 3174897. DOI: https://doi.org/10.1155/2018/3174897. [cited 6 September 2023]
Reilly CR, Cuesta-Fernandez A, Kayaleh OR. Successful gestation and delivery using clopidogrel for secondary stroke prophylaxis: a case report and literature review. Arch Gynecol Obstet. 2014;290(3):591-4. doi: 10.1007/s00404-014-3269-6. [cited 2 October 2023]
Yarrington CD, Valente AM, Economy KE. Cardiovascular management in pregnancy: Antithrombotic agents and antiplatelet agents. Circulation. 2015;132(14):1354-64. DOI: 10.1161/CIRCULATIONAHA.114.003902. [cited 2 October 2023]
Nana M, Morgan H, Moore S, Lee ZX, Ang E, Nelson-Piercy C. Antiplatelet therapy in pregnancy: A systematic review. Pharmacol Res. 2021;168:105547. Doi: 10.1016/j.phrs.2021.105547. [cited 2 October 2023]
De Santis M, De Luca C, Mappa I, Cesari E, Mazza A, Quattrocchi T, Caruso A. Clopidogrel treatment during pregnancy: a case report and a review of the literature. Intern Med. 2011;50(16):1769-73. doi: 10.2169/internalmedicine.50.5294.[cited 5 October 2023]
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