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  2. Vol 55, No 2 (2023)
  3. Widhani

A Case Report of Hereditary Angioedema: Challenges in Diagnosis and Management

Alvina Widhani, Suzy Maria, Rifky Yulian, Anshari Saifuddin Hasibuan, Sukamto Koesnoe

Abstract


Hereditary angioedema (HAE) is a rare autosomal dominant genetic disorder which causes bradykinin mediated angioedema. Although it can be life threatening, HAE may be underdiagnosed due to a lack of awareness of the disease and limited access to laboratory testing. Here, we report a case of HAE which was diagnosed only after the patient was referred for COVID-19 vaccination even though he had been experiencing recurrent angioedema for the past 30 years. 


Keywords


hereditary; angioedema; diagnosis; management

References


Wilkerson RG, Moellman JJ. Hereditary angioedema. Emerg Med Clin North Am. 2022;40:99–118.

Jindal AK, Bishnoi A, Dogra S. Hereditary angioedema: Diagnostic algorithm and current treatment concepts. Indian Dermatol Online J. 2021;12(6):796–804.

Minafra FG, Goncalves TR, Alves TM, Pinto JA. The mortality from hereditary angioedema worldwide: A review of the real-world data literature. Clin Rev Allergy Immunol. 2022; 62(1):232-9.

The international WAO/EAACI guideline for the management of hereditary angioedema—The 2021 revision and update. World Allergy Organ J. 2022; 15(3):100627.

Soni P, Kumar V, Alliu S, Shetty V. Hereditary angioedema (HAE): a cause for recurrent abdominal pain. BMJ Case Rep. 2016; 2016: bcr2016217196.

Zafra H. Hereditary angioedema: a review. WMJ. 2022;121(1):48-53.

Kaplan AP, Joseph K. Complement, kinins, and hereditary angioedema: mechanisms of plasma instability when C1 inhibitor is absent. Clinic Rev Allerg Immunol. 2016;51:207–15.

Abdulkarim A, Craig TJ. Hereditary angioedema. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022.

Fijen LM, Levi M, Cohn DM. COVID-19 vaccination and the risk of swellings in patients with hereditary angioedema. J Allergy Clin Immunol Pract 2021;9(11):4156-8.


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