Urease Levels and Gastritis Stage in Dyspeptic Patients

Authors

  • Muhammad Miftahussurur 1. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia 2. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia 3. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan
  • Chyntia Dewi Maharani Putri Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Titong Sugihartono Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Ari Fahrial Syam Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta 10430, Indonesia
  • Herry Purbayu Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Diah Priyantini Faculty of Nursing, Universitas Airlangga, Surabaya 60115, Indonesia
  • Hartono Kahar Department of Clinical Pathology, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60131, Indonesia
  • Yudith Annisa Ayu Rezkitha 1. Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia 2. Faculty of Medicine, Muhammadiyah University of Surabaya, Surabaya 60113, Indonesia
  • Iswan Abbas Nusi Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Poernomo Boedi Setiawan Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Ummi Maimunah Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Langgeng Agung Waskito Institute of Tropical Disease, Universitas Airlangga, Surabaya 60115, Indonesia
  • Ulfa Kholili Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Budi Widodo Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Amie Vidyani Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Husin Thamrin Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia
  • Gontar Alamsyah Siregar Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, North Sumatra University, Medan, 20115, Indonesia
  • Reny I’tishom Department of Medical Biology, Faculty of Medicine, Universitas Airlangga, Surabaya 60131, Indonesia
  • Tomohisa Uchida Department of Molecular Pathology, Oita University Faculty of Medicine, Yufu 879-5593, Japan
  • Yoshio Yamaoka 1. Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine-Dr. Soetomo Teaching Hospital, Universitas Airlangga, Surabaya 60286, Indonesia 2. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu 879-5593, Japan

Keywords:

Dyspepsia, Gastritis severity, Urea Breath Test, Cancer

Abstract

Background: Dyspepsia is a frequent main symptom of inpatients and outpatients scenario in Indonesia. However, the number of endoscopy facilities are still low, thus the use of non-invasive method to detect gastritis is necessary. We measured the relationship between urease levels and the stage of gastritis in dyspeptic adult patients. Methods: A cross-sectional study included outpatient dyspepsia patient from November 2018 to February 2019. We examined 14C-Urea Breath Test (UBT) and determined the stage of gastritis based on the Updated Sydney System classification. Results: The urease level of acute and chronic gastritis positive patients were higher than negative patients (p = 0.001, r = 0.353; p <0.0001, r = 0.433, respectively). The AUC value of 14C-UBT to detect acute, chronic, and atrophic gastritis are 0.889, 0.632 and 0.544, respectively. The best cut-off points of 14C-UBT to predict acute gastritis was ≥26.50δ‰ with sensitivity and specificity being 88.89% and 63.95%, respectively. Whereas the best cut-off points for chronic gastritis was ≥34.50δ‰ with 82.89% sensitivity, 63.16% specificity. As for atrophic gastritis, it showed very low AUC value, hence it is not a sufficient test modality to predict atrophic gastritis cases. Conclusion: 14C-UBT is sufficient for predicting acute or chronic gastritis but not for atrophic gastritis.

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Published

2022-04-08

How to Cite

Miftahussurur, M., Putri, C. D. M., Sugihartono, T., Syam, A. F., Purbayu, H., Priyantini, D., Kahar, H., Rezkitha, Y. A. A., Nusi, I. A., Setiawan, P. B., Maimunah, U., Waskito, L. A., Kholili, U., Widodo, B., Vidyani, A., Thamrin, H., Siregar, G. A., I’tishom, R., Uchida, T., & Yamaoka, Y. (2022). Urease Levels and Gastritis Stage in Dyspeptic Patients. Acta Medica Indonesiana, 54(1), 42. Retrieved from https://actamedindones.org/index.php/ijim/article/view/1927

Issue

Vol. 54 No. 1 (2022): Acta Medica Indonesiana

Section

ORIGINAL ARTICLE

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