An East-Asian-type cagA Helicobacter pylori Infected Patient with Clinical Manifestation of Gastric Ulcer

Authors

  • Yudith Annisa Ayu Rezkitha Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia
  • Muhammad Miftahussurur Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan
  • Iswan A Nusi Department of Internal Medicine, Faculty of Medicine Universitas Airlangga - dr. Soetomo Teaching Hospital, Surabaya, Indonesia
  • Ummi Maimunah Department of Internal Medicine, Faculty of Medicine Universitas Airlangga - dr. Soetomo Teaching Hospital, Surabaya, Indonesia
  • Pangestu Adi Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia.
  • Yoshio Yamaoka Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan

Keywords:

Helicobacter pylori, Gastric ulcer, East-Asian-type cagA, vacA

Abstract

We reported a male, 72 yo, Chinese ethnic with chief complaint black mushy defecation. Physical examination revealed pale on conjunctival palpebra which confirmed as anemia on complete blood count. Gastroduodenoscopy revealed a 3 mm ulcer at the antrum (Forrest stage III). H. pylori infection was positive based on five different test methods (urinary antibody tests, rapid urease test, culture, histology ad immunohistochemistry). Used polymerase chain reaction-based sequencing, we found the patient infected by CagA producing, East-Asian-type cagA and vacA s1m1-strain. Further analysis using 7 housekeeping genes confirmed that the strain categorized in to hspEAsia group. The patient was given continuous intravenous infusions of proton pump inhibitor and standard triple therapy regimens eradication of H. pylori.

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Published

2017-02-01

How to Cite

Rezkitha, Y. A. A., Miftahussurur, M., Nusi, I. A., Maimunah, U., Adi, P., & Yamaoka, Y. (2017). An East-Asian-type cagA Helicobacter pylori Infected Patient with Clinical Manifestation of Gastric Ulcer. Acta Medica Indonesiana, 48(4), 307-313. Retrieved from https://actamedindones.org/index.php/ijim/article/view/264

Issue

Vol. 48 No. 4 (2016): Acta Medica Indonesiana

Section

CASE REPORT

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